Sedation may be enhanced upon concomitant use of antihistamines in general with central nervous system depressants such as barbiturates, alcohol, hypnotics, opioid analgesics, anxiolytics sedatives and neuroleptics.
The use of cetirizine hydrochloride with drugs that inhibit the cytochrome P450 microsomal enzymes such as azithromycin, erythromycin and ketoconazole, did not cause clinically significant changes.
Effects of alcohol and other CNS depressants are enhanced by cetirizine hydrochloride.
Pharmacokinetic properties of ritonavir, HIV protease Inhibitor, are not affected by cetirizine hydrochloride.
                                
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