Zydol Dosage/Direction for Use

When determining the appropriate dose of Butorphanol Tartrate Injection, several factors should be considered including age, body weight, physical condition, underlying medical issues, concurrent medications, the type of anesthesia to be used, and the nature of the surgical procedure.
Extra caution is advised when using butorphanol in elderly patients, those with hepatic or renal impairment, or during labor.
The following dosage recommendations apply to patients with normal hepatic and renal function who are not receiving other central nervous system (CNS)-active medications.
Use for Pain Relief: Intravenous (IV): The usual recommended single IV dose is 1 mg, repeated every 3 to 4 hours as needed. The effective dosage range is 0.5 to 2 mg, depending on pain severity, given every 3 to 4 hours.
Intramuscular (IM): The usual single IM dose is 2 mg, particularly in patients who can remain recumbent in case of drowsiness or dizziness. Doses may be repeated every 3 to 4 hours as necessary. The effective range is 1 to 4 mg, repeated every 3 to 4 hours. There is insufficient clinical data to support single doses exceeding 4 mg.
Use as Preoperative/Preanesthetic Medication: Preoperative dosage should be individualized. The usual adult dose is 2 mg IM, administered 60 to 90 minutes before surgery. This provides sedative effects comparable to 10 mg of morphine or 80 mg of meperidine.
Use in Balanced Anesthesia: The usual dose is 2 mg IV administered shortly before induction. During anesthesia, 0.5 to 1 mg IV may be given in increments. Doses can be increased up to 0.06 mg/kg (approximately 4 mg/70 kg), depending on prior administration of sedatives, analgesics, or hypnotics. Total doses range from 4 mg to 12.5 mg (or 0.06 mg/kg to 0.18 mg/kg), depending on individual requirements.
Use in Labor: In full-term patients in early labor, a dose of 1 to 2 mg IV or IM may be administered, and repeated after 4 hours if needed. Alternative analgesia should be used for pain associated with delivery or if delivery is expected to occur within 4 hours.
If butorphanol is used with other drugs that may enhance its effects, the lowest effective dose should be used.