Zydol Contraindications

Opioid Dependence: Butorphanol is contraindicated in patients who are opioid dependent. Due to its opioid antagonist properties, butorphanol may precipitate acute opioid withdrawal characterized by anxiety, agitation, mood changes, hallucinations, dysphoria, weakness, and diarrhea.
Recent or Concurrent Use of Opioid Analgesics: Because opioid tolerance cannot be reliably assessed in patients who have recently received repeated doses of opioid analgesics, butorphanol is contraindicated in such patients due to the risk of precipitating withdrawal.
Head Injury or Increased Intracranial Pressure: Butorphanol is contraindicated in patients with head injury or elevated intracranial pressure, as its use may cause carbon dioxide retention, drug-induced miosis, and alterations in mental status that can obscure neurologic evaluation.
Significant Respiratory Impairment: Butorphanol is contraindicated in patients with significant respiratory depression or impaired respiratory function, including those receiving other CNS depressants or those with underlying CNS disease affecting respiratory control.
Cardiovascular Instability: Butorphanol is contraindicated in patients with acute myocardial infarction, ventricular dysfunction, or coronary insufficiency when an increase in cardiac workload may pose a significant risk. Severe hypertension has been reported during therapy; if it occurs, therapy must be discontinued and appropriate treatment initiated.