Utoral Special Precautions

Patients who are in a poor nutritional state. Patients with severe surgical pus. Patients with hepatic impairment. Patients with heart disease or history of it.
General: The daily dose should not exceed 1 g.
In animal studies, Fluorouracil has been shown to be teratogenic. Therefore, it should not be administered to pregnant women or women suspected of being pregnant.
Severe enteritis (hemorrhagic, ischemic and necrotic enteritis) and dehydration may occur; it therefore, should be observed carefully. If severe abdominal pain or diarrhea occurs the administration should be discontinued and appropriate therapy instituted. If dehydration symptoms occur, appropriate therapy including liquor supplement should be initiated.
Use in Pregnancy & Lactation: The safety of this medicinal product for use in human pregnancy has not been established. UTORAL should, therefore, not be used during pregnancy.
It is not known whether this drug is excreted in human milk. Because many drugs are excreted in human milk and the potential for serious adverse reactions in nursing infants from UTORAL, a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother.