Utoral Adverse Reactions

Psychoneura: Rarely, extrapyramidal symptom, facioplegia, dyslogia, ataxia, eye trembling, consciousness disorder, convulsion, disorientation, numbness of acra, leukoencephalopathy, parkinsonism may occur; therefore, the patients should be monitored sufficiently. If they occur, the administration should be discontinued. Malaise, and occasionally, dizziness may also occur.
Gastrointestinal Effect: Anorexia, nausea, vomiting and changing of taste can occur. Severe enteritis (hemorrhagic, ischemic, necrotic enteritis) may occur, therefore the patients should be sufficiently observed. If severe abdominalgia or diarrhea occurs, the administration should be discontinued and appropriate therapy instituted.
Cardiovascular: Congestive heart failure, cardiac infarction, angina, pain, ECG abnormalities, chest pain may occur. If any symptoms appear, the dose should be reduced or discontinued.
Hematologic: Pancytopenia, leukopenia, neutropenia, occasional cases of anemia, thrombocytopenia may occur. If any hematologic abnormality occurs, the administration should be discontinued and/or appropriate therapy instituted.
Hepatic: Rare case of severe hepatic disorder such as hepatitis may occur; therefore, liver function must be regularly tested.
Renal: Renal function and proteinuria have been reported.
Dehydration: If severe diarrhea or melena appears, the administration should be discontinued and/or appropriate therapy such as dehydration instituted.
Others: Stomatitis, systemic malaise, and occasionally alopecia may occur.