Fluorouracil is used for the palliative treatment of carcinoma of the colon, rectum, breast, stomach, and pancreas that is not amenable to surgery or irradiation. The drug is also used as an adjunct to surgery for the treatment of various solid tumors. Fluorouracil is less effective in the treatment of carcinomas of the ovary, cervix, urinary bladder, liver, and pancreas, although improvements in some patients have been reported.