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Transient elevations of BUN and serum creatinine have been observed, at recommended doses, the nephrotoxic potential of Ceftriaxone is same as other cephalosporins. Since Ceftriaxone is excreted both via renal and bile patients with renal failure normally require no adjustment in dosage when usual doses of Ceftriaxone are administered.
Dosage adjustments are not necessary in patients with hepatic dysfunction; however in patients with both renal failure and hepatic dysfunction, dosage should not exceed more than 2 g daily with close monitoring of serum concentrations.
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