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Traxulev

Traxulev

Manufacturer:

Inject Care Parenterals

Distributor:

HLM Pharma
Concise Prescribing Info Full Prescribing Info Contents Description Action Indications/Uses Dosage/Direction for Use Overdosage Contraindications Warnings Special Precautions Use In Pregnancy & Lactation Adverse Reactions Drug Interactions Caution For Usage Storage MIMS Class ATC Classification Regulatory Classification Presentation/Packing
Concise Prescribing Info
Contents
Per 1 g/500 mg powd for inj Ceftriaxone 1 g, sulbactam 500 mg
Indications/Uses
Meningitis, nosocomial infections, surgical prophylaxis, UTI (complicated by underlying urological abnormalities), skin & soft tissue infections (eg, cellulitis, erysipelas), cholecystitis, osteomyelitis, STD (gonorrhoea, chancroid, syphilis), chronic suppurative bacterial otitis media & infections in dialysis unit.
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Dosage/Direction for Use
Adult Ceftriaxone 1-2 g once daily or bid in equally divided doses. Max total daily dose: 4 g. Childn Skin & soft tissue infection Ceftriaxone 50-75 mg/kg once daily or bid in equally divided doses. Max total daily dose: 1 g. Acute bacterial otitis media 50 mg/kg (not to exceed 1 g) as single IM dose. Meningitis Initially ceftriaxone 100 mg/kg (not to exceed 4 g). Administer daily dose as once daily or every 12 hr in equally divided doses for 7-14 days. Serious infection other than meningitis Ceftriaxone 50-75 mg/kg every 12 hr in divided doses. Max total daily dose: 2 g.
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Overdosage
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Contraindications
Hypersensitivity to cephalosporins or any penicillins.
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Warnings
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Special Precautions
Individuals w/ history of hypersensitivity reactions to multiple allergens. Consider pseudomembranous colitis in patients who develop diarrhea in association w/ antibiotic use. Transient elevations of BUN & serum creatinine. Patients w/ both renal failure & hepatic dysfunction. Should not be used in pregnancy unless absolutely indicated. Lactation.
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Use In Pregnancy & Lactation
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Adverse Reactions
Loose stools or diarrhoea, nausea, vomiting, stomatitis & glossitis; superinfection caused by non-susceptible microorganisms; haematological reactions including anaemia (all grades), haemolytic anaemia, granulocytopenia, leucopenia, neutropenia, thrombocytopenia & eosinophilia.
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Drug Interactions
Precipitation of ceftriaxone-Ca w/ Ca-containing soln. Antagonistic effects have been observed in vitro w/ chloramphenicol. Potential to cause hypoprothrombinaemia resulting in increased risk of bleeding w/ anticoagulants. May adversely affect efficacy of oral hormonal contraceptives. Incompatible w/ amsacrine, vancomycin, fluconazole & aminoglycosides. May give false +ve results for Coombs' test; test for galactosemia; non-enzymatic methods for glucose determination in urine eg, Cu reduction methods.
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Caution For Usage
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Storage
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Description
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Action
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MIMS Class
Cephalosporins
ATC Classification
J01DD63 - ceftriaxone and beta-lactamase inhibitor ; Belongs to the class of third-generation cephalosporins. Used in the systemic treatment of infections.
Regulatory Classification
Rx
Presentation/Packing
Form
Traxulev 1 g/500 mg powd for inj
Packing/Price
1's