Tidomet: The therapeutic or adverse effects of levodopa may be affected by interactions with a variety of drugs. Mechanisms may include effects on catecholamine metabolizing enzymes, neurotransmitters, or receptor sites, effects on the endocrine system, and effects on gastrointestinal absorption. Drugs that modify gastric emptying may affect the absorption of levodopa.
Tidomet CR: Symptomatic postural hypotension may occur. If co-careldopa is added to the treatment of patient receiving antihypertensive drugs. Hypertension and dyskinesia results from the concomitant use of tricyclics and Tidomet CR. Phenothiazines and butyrophenones may reduce the therapeutic effects of Tidomet CR. Phenytoin and papaverine reverse beneficial effects of levodopa.
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