Tidomet/Tidomet CR Dosage/Direction for Use

Tidomet: Carefully titrate dosage in each patient. Initiate treatment with 1 tablet of co-careldopa. Plus 3 times a day. Dosage may be increased by 1 tablet day or or every other day as necessary until a dosage of 8 tablets of co-careldopa plus per day is reached. If co-careldopa LS is used, initiate 1 tablet 3 or 4 times a day and increased by 1 tablet every day or every other day until a total 8 tablets i.e. 2 tablets 4 times a day is reached. Transferring patients from levodopa to co-careldopa, levodopa must be discontinued at least before 8 hours. ¹/₄th of the previous levodopa dosage may be started as co-careldopa. Patients taking less than 1500 mg of levodopa per day should be started on one tablet of co-careldopa. Plus 3-4 times a day. Maintenance therapy should be individualized and adjusted according to the desired therapeutic response.
When a greater proportion of carbidopa is required, one tablet of co-careldopa plus may be substituted for each tablet of co-careldopa LS. When more levodopa is required co-careldopa forte should be substituted at a dosage of 1 tablet 3 or 4 times a day. If necessary, the dosage may be increased by ¹/₂ or 1 tablet every day or every other day to a maximum of 8 tablets a day. The occurrence of of involuntary may require dosage reduction; Blepharospasm may be a useful early sign of excess dosage in some patients.
Tidomet CR: For Patients already receiving levodopa therapy and for those currently receiving levodopa alone: Initial dose is 1 tablet twice daily adjusted according to response at intervals of not less than 3 days. It is recommended that for patients whose are not already receiving initial dosages should not exceed 600 mg of levodopa. Or as prescribed by the physician.
For patients already receiving a conventional preparation: Initial dose similar to that of the conventional preparation but the dosing intervals should be prolonged and are normally between 4 to 12 hours. The initial substitution of the controlled release preparation should provide not more than 10% more levodopa than was previously given for doses greater than 900 mg daily. Doses and intervals may then be altered according to clinical response, allowing at least 3 days between adjustments. Up to 30% more levodopa may be required in the controlled release preparation than was previously administered in the conventional preparation. Or as prescribed by the physician.
Average maintenance dose of controlled release preparation lies between the range of Carbidopa 100 mg with Levodopa 400 mg to Carbidopa 400 mg with Levodopa 1.6 g.
Swallow whole tablet, do not crush or chew.