Swich Drug Interactions

No clinically significant drug interactions have been reported during the course of clinical studies. Histamine H2-antagonists and antacids reduce the bioavailability of Cefpodoxime.
Probenecid reduces the excretion and the contraceptive effect of estrogens.
Tablet: Oral anticoagulants: Simultaneous administration of cefpodoxime with warfarin may augment its anticoagulant effects. There have been many reports of increase in oral anti-coagulant activity in patients receiving antibacterial agents, including cephalosporins.
Suspension: As with other cephalosporins, isolated cases showing development of a positive Coombs' test have been reported.
Studies have shown that bioavailability is decreased by approximately 30% when Cefpodoxime is administered with drugs which neutralize gastric pH or inhibit acid secretions. Therefore, such drugs as antacids of the mineral type and H-blockers such as ranitidine, which can cause an increase in gastric pH, should be taken 2 to 3 hours after Cefpodoxime administration.
The bioavailability increases if the product is administered during meals.
A false positive reaction for glucose in the urine may occur with Benedict's or Fehling's solutions or with copper sulphate test tablets, but not with test based on enzymatic glucose oxidase reactions.