Swich

FC tab: Infections caused by susceptible pathogens including Enterobacteriaceae, Staph spp., Staph aureus (methicillin-susceptible), Strep groups A, B, C & G, Strep pneumoniae, Strep pyogenes, Haemophilus influenza, Moraxella catarrhalis, Proteus mirabilis. Powd for susp: Susceptible infections including gonorrhoea, otitis media, pharyngitis, lower resp tract infections eg, bronchitis, & UTI.

FC tab Adult & adolescent w/ normal renal function Acute bacterial sinusitis, acute exacerbation of chronic bronchitis, bacterial pneumonia 200 mg bid. Renal impairment CrCl 39-10 mL/min Single dose every 24 hr (ie, ½ of usual adult dose), <10 mL/min Single dose every 48 hr (ie, ¼ of usual adult dose), haemodialysis patient Single dose after each dialysis session. Powd for susp Adult w/ normal renal function Sinusitis 200 mg bid. Other URTI 100 mg bid. Lower resp tract infection including acute bronchitis, relapse or exacerbation of chronic bronchitis & bacterial pneumonia 100-200 mg bid, dependent on severity of infection. Uncomplicated lower UTI 100 or 200 mg bid. Uncomplicated gonococcal urethritis 200 mg as single dose. Skin & soft tissue infection 200 mg bid. Infant & ped patient 2 mth-12 yr Acute otitis media 5 mg/kg every 12 hr (max 200 mg daily) for 5 days. Total dose: 10 mg/kg daily (max 400 mg daily). Pharyngitis &/or tonsillitis 5 mg/kg every 12 hr (max 100 mg daily) for 5-10 days. Total dose: 10 mg/kg daily (max 200 mg daily). Acute maxillary sinusitis 5 mg/kg every 12 hr (max 200 mg daily) for 10 days. Total dose: 10 mg/kg daily (max 400 mg daily). Renal impairment CrCl 39-10 mL/min Unit dose as single dose every 24 hr (ie, ½ of usual adult dose), <10 mL/min Unit dose as single dose every 48 hr (ie, ¼ of usual adult dose), haemodialysis patient Unit dose after each dialysis session. Unit dose: Either 100 or 200 mg, depending on type of infection.

Should be taken with food.

Hypersensitivity to cefpodoxime or any other cephalosporins. Not to be taken by patients w/ rare hereditary problems of galactose intolerance, Lapp lactase deficiency or glucose-galactose malabsorption.

Not preferred antibiotic for staphylococcal pneumonia & do not use in atypical pneumonia caused by organisms eg, Legionella, Mycoplasma & Chlamydia. Not recommended for pneumonia due to Strep pneumoniae. Discontinue treatment immediately & initiate adequate emergency measures in case of severe hypersensitivity reactions. Establish whether patient has history of severe hypersensitivity reactions to other cephalosporins or any other type of β-lactam agent before beginning treatment. Patients w/ history of non-severe hypersensitivity to other β-lactam agents; sensitive to penicillin. Consider antibacterial agent-associated & pseudo-membranous colitis in patients who present w/ diarrhoea during or subsequent to administration; discontinuation of therapy & administration of specific treatment for Clostridium difficile. Do not give medicinal products that inhibit peristalsis. Patients w/ history of GI disease, particularly colitis. Neutropenia & agranulocytosis may develop particularly during extended treatment. Monitor blood count for cases of treatment lasting >10 days & discontinue treatment if neutropenia is found. Can produce +ve Coomb's test & very rarely, haemolytic anaemia. Cross-reactivity may occur w/ penicillin. Monitor changes in renal function when given concurrently w/ potentially nephrotoxic drugs eg, aminoglycosides &/or potential diuretics. Prolonged use may result in overgrowth of non-susceptible organisms (Candida & Clostridium difficile). False +ve reaction for glucose in urine may occur w/ Benedict's or Fehling's soln or w/ Cu sulphate test tab. Severe renal insufficiency. Pregnancy & lactation. FC tab: Not to be taken by patients w/ rare hereditary problems of galactose malabsorption. Sunset yellow (E110) may cause allergic reactions.

Powd for susp: GI disorders eg, antibiotic-associated colitis (rarely), nausea, vomiting & abdominal pain; rash, urticaria, itching; changes in renal function.

Reduced bioavailability w/ histamine H₂ antagonists & antacids. Reduced excretion w/ probenecid; reduced contraceptive effect of estrogens. May augment anticoagulant effects of warfarin.

Cephalosporins

J01DD13 - cefpodoxime ; Belongs to the class of third-generation cephalosporins. Used in the systemic treatment of infections.

Rx