Strepsils MaxPro Direct Drug Interactions

Flurbiprofen should be avoided in combination with: Acetylsalicylic Acid: Unless low-dose acetylsalicylic acid (not above 100 mg daily or local prophylactic dose for cardiovascular protection) has been advised by a doctor, as this may increase the risk of adverse reactions (see Precautions).
Other NSAIDs (including Ibuprofen and Cyclooxygenase-2-Selective Inhibitors): Avoid concomitant use of 2 or more NSAIDs as this may increase the risk of adverse effects (see Precautions).
Flurbiprofen should be used with caution in combination with: Anti-coagulants: NSAIDs may enhance the effects of anti-coagulants, such as warfarin (see Precautions).
Anti-platelet agents and Selective Serotonin Reuptake Inhibitors (SSRIs): Increased risk of gastrointestinal bleeding (see Precautions).
Antihypertensives (ACE inhibitors and Angiotensin II Antagonists) and Diuretics: NSAIDs may reduce the effect of diuretics and other antihypertensive drugs. This may enhance nephrotoxicity caused by inhibition of cyclooxygenase, especially in patients with compromised renal function (Patients should be adequately hydrated).
Alcohol: May increase the risk of adverse reactions, especially of bleeding in the gastrointestinal tract.
Cardiac Glycosides: NSAIDs may exacerbate cardiac failure, reduce glomerular filtration rate (GFR), and increase plasma glycoside levels.
Ciclosporin: Increased risk of nephrotoxicity.
Corticosteroids: Increased risk of gastrointestinal ulceration or bleeding (see Precautions).
Lithium: There is evidence for potential increases in plasma levels of lithium.
Methotrexate: There is a potential for an increase in plasma levels of methotrexate.
Mifepristone: NSAIDs should not be used for 8-12 days after mifepristone administration as NSAIDs can reduce the effect of mifepristone.
Quinolone Antibiotics: Animal data indicate that NSAIDs can increase the risk of convulsions associated with quinolone antibiotics. Patients taking NSAIDs and quinolones may have an increased risk of developing convulsions.
Tacrolimus: Possible increased risk of nephrotoxicity when NSAIDs are given with tacrolimus.
Zidovudine: Increased risk of haematological toxicity when NSAIDs are given with zidovudine.