Rotasiil-Liquid Drug Interactions

Immunosuppressive therapies including irradiation, antimetabolites, alkylating agents, cytotoxic drugs and corticosteroids (used in greater than minimal doses), may reduce the immune response to vaccines.
ROTASIIL-Liquid can be administered concomitantly with other vaccines of the infant immunization programme, including combined diphtheria, tetanus toxoid and pertussis vaccine (DTP), inactivated poliovirus vaccine (IPV), oral polio vaccine (OPV), H. influenzae type b conjugate (Hib), hepatitis B vaccine. No interaction studies have been performed with ROTASIIL-Liquid in infants with other medicinal products.
In phase 2/3 study of ROTASIIL-Liquid, three doses of either ROTASIIL-Liquid or ROTASIIL (Freeze-Dried) were administered 4 weeks apart (minimum interval of 4 weeks and maximum of 6 weeks). All subjects received concomitantly other UIP vaccines as per the national immunization schedule (DTwP-HepB-Hib, bOPV, IPV). Other than UIP, OPV was also administered during national/sub-national immunization days; BCG and Pneumococcal vaccines were also allowed during the study period.