Each gram contains: Tolnaftate, USP 10 mg.
Tolnaftate, a thioester of β-naphthol, is a synthetic antifungal drug with either fungicidal or fungistatic property that is used to treat ringworm, athlete's foot and jock itch.
It is a selective, reversible and non-competitive inhibitor of membrane-bound squalene-2, 3-epoxidase, an enzyme involved in the biosynthesis of ergosterol. Inhibition leads to the accumulation of squalene and a deficiency in ergosterol, an essential component of fungal cell walls, thereby increasing membrane permeability, disrupting cellular organization and causing cell death. In addition, this agent may also distort the hyphae and stunts mycelial growth in susceptible fungi.
Pharmacology: Pharmacokinetics: There is minimal absorption from the skin with topical application of tolnaftate 10 mg/g ointment.
Tolnaftate, 10 mg/g ointment, is an effective fungicide against dermatophytes - Malassezia furfur, Epidermophyton floccosum and species of Trichophyton (T. rubrum, T. mentaggrophytes, T. tonsurans) and Microsporum (M. canis, M. audouini, M. gypseum) that cause superficial tinea infections such as tinea pedis, tinea cruris, tinea manuum and tinea corporis.
The cure rate for tinea pedis is about 80%.
Tolnaftate is also effective against Pityrosporum obiculare and is used in the treatment of pityriasis versicolor.
The drug does not suppress Candida and is ineffective against bacterial infections.
Tolnaftate is applied to affected part of the skin and surrounding areas twice daily. The treatment duration may last from 2 to 6 weeks.
When necessary, application of tolnaftate may be repeated.
Tolnaftate is not used to treat deep infections of hair follicles or of nail beds.
Concomitant use of tolnaftate with griseofulvin, a systemic drug, may be considered when treating infections in hyperkeratotic lesions or in the palms and soles which are normally thick in layers.
Do not apply tolnaftate near the eyes, mouth, nose, vagina, and other mucous membranes.
Allergic and toxic reactions such as contact dermatitis and irritation are rarely reported with the use of topical tolnaftate.
Burning sensation and maceration at the area of the lesion are also occasionally reported with the use of tolnaftate which are said to be caused by endotoxins of fungi that were eradicated.
Store at temperatures not exceeding 25°C.
D01AE18 - tolnaftate ; Belongs to the class of other antifungals for topical use.
RiteMED Tolnaftate oint 10 mg/g
15 g x 1's (P250/tube)
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