RiteMED Fluoxetine Overdosage

A report involving cases in which Fluoxetine was taken in overdosage without other drugs found that the main symptoms were tachycardia, drowsiness, tremor and nausea and vomiting. These were considered relatively minor, and were of short duration, and supportive care was considered to be the only intervention necessary.
Treatment of overdosage with an SSRI involves appropriate symptomatic and supportive therapy. Activated charcoal may be given by mouth if the amount ingested was large and treatment is within an hour of ingestion. Dialysis, hemoperfusion, exchange transfusion, and measures to increase urine production are considered unlikely to be of benefit.
The UK Poisons Information Service considers the benefits of gastric decontamination in the management of overdosage with SSRIs to be uncertain. However, it is suggested that oral activated charcoal may be considered if this is given within 1 hour of ingestion and the quantity of SSRI exceeds the following amount: Fluoxetine: 500 mg (adult); 5 mg/kg (child).