RiteMED Fluoxetine Contraindications

Hypersensitivity to Fluoxetine or any of its excipients.
Diabetes mellitus: Changes in blood sugar concentrations may occur in patients with diabetes treated for depression with SSRIs.
Gastrointestinal disorders: For the opinion that the SSRIs may produce a clinically important increase in the risk of upper gastrointestinal bleeding in patients with a high risk of such bleeding.
Glaucoma: For reference to SSRIs precipitating or exacerbating symptoms of glaucoma.
Mania: Hypomania or mania has been reported with the SSRIs; it is recommended that SSRIs should be withdrawn in any patient entering a manic phase.
Surgery: In patients undergoing orthopedic surgery, the risk of perioperative blood loss was significantly increased in those taking serotonergic antidepressant (specifically clomipramine, fluoxetine, fluvoxamine, paroxetine, sertraline and venlafaxine) when compared to those on non-serotonergic antidepressants. In addition, there was a significant increase in the need for blood transfusion during surgery in those on serotonergic antidepressants compared with those not receiving antidepressant medications.
Withdrawal: In general, withdrawal reactions tend to occur within 3 days of stopping on SSRI or related antidepressant although delay of up to 2 weeks may be noted with Fluoxetine. Common symptoms include dizziness, numbness and tingling, gastrointestinal disturbances (particularly nausea and vomiting), headache, sweating, anxiety and sleep disorders. In some cases, withdrawal symptoms may be severe and disabling.