RiteMED Cloxacillin Special Precautions

Cloxacillin shares the toxic potentials of the penicillins, including the risk of hypersensitivity reactions and the usual precautions of penicillin therapy should be observed. Prior to initiation of therapy with cloxacillin, careful inquiry should be made concerning previous hypersensitivity reactions to penicillins. There is clinical and laboratory evidence of partial cross-allergenicity among penicillins and other β-lactam antibiotics including cephalosporins, cephamycins and 1-oxo-β-lactams.
Evaluate renal, hepatic and hematologic systems periodically during prolonged therapy with cloxacillin.
Prolonged use of penicillinase-resistant penicillins may result in overgrowth of nonsusceptible organisms, including fungi or gram-negative bacteria eg, Pseudomonas. Discontinue cloxacillin and institute appropriate measures if supra- or superinfection occurs.