RiteMED Cloxacillin Adverse Reactions

Hypersensitivity: Rash (morbilliform, maculopapular, urticarial or erythematous), fever, eosinophilia, pruritus and serum sickness-like reactions with fever, chills and myalgia. Eosinophilia reportedly occurs in 5-38% of patients receiving a penicillinase-resistant penicillin and fever or rash occurs in 2-6% of patients receiving one of these drugs. Rarely, anaphylaxis.
Gastrointestinal: Frequently, nausea, vomiting, epigastric distress, loose stools, diarrhea and flatulence. Rarely, antibiotic-associated pseudomembranous colitis.
Renal: Rarely, transient microscopic hematuria.
Hematologic: Rarely, eosinophilia, hemolytic anemia, transient neutropenia, leukopenia, granulocytopenia, thrombocytopenia and agranulocytosis.
Hepatic: Occasionally, transient elevations in serum concentrations of alkaline phosphatase, AST, ALT, bilirubin and LDH; these reactions are more common in infants. One case of intrahepatic cholestasis has been reported.