Cardiovascular: Bradycardia, postural hypotension which may be associated with syncope, hypotension, heart failure, heart block, supraventricular tachycardia, atrial fibrillation, atrial flutter, ventricular tachycardia, cardiac reinfarction, total cardiac arrest, nonfatal cardiac arrest, cardiogenic shock, development of ventricular septal defect, development of mitral regurgitation, cardiac failure, arrhythmias, sick sinus syndrome, left ventricular insufficiency, intermittent claudication, Raynaud's phenomenon, cold extremities, deterioration in heart failure, increase in early death secondary to bradycardia and shock.
Gastrointestinal: Diarrhea, nausea, dry mouth, mesenteric arterial thrombosis, ischemic colitis, gastrointestinal disturbance including indigestion, constipation, hepatic toxicity including intrahepatic cholestasis.
Hematologic: Nonthrombocytopenic or thrombocytopenic purpura, thrombocytopenia, agranulocytosis, increased antinuclear antibodies (ANA).
Hypersensitivity reactions: Angioedema, urticaria, fever combined with aching and sore throat, laryngospasm, and respiratory distress.
Metabolic and nutritional: Elevated liver enzymes, aspartate aminotransferase (AST), blood urea nitrogen, serum creatinine, bilirubin, hypoglycemia.
Musculoskeletal: Ataxia, leg pain.
Nervous: Dizziness, vertigo, light-headedness, tiredness, fatigue, lethargy, drowsiness, depression, vivid dreams, hallucination, headache, psychoses, reversible mental depression progressing to catatonia (acute reversible syndrome characterized by disorientation of time and place), short-term memory loss, emotional lability with slightly clouded sensorium, decreased performance on neuropsychometrics, confusion, mood changes, nightmares, paresthesia, vertigo, insomnia, sleep disturbance.
Reproductive: Impotence, Peyronie's disease.
Respiratory: Wheezing, dyspnea, bronchospasm, pulmonary emboli, asthma, nasal congestion Skin and appendages: Psoriasiform skin reactions, exacerbation of psoriasis, reversible alopecia, skin rash, erythematous rash.
Special senses: Visual disturbance, dry eyes, conjunctivitis, tinnitus, otitis.
Urogenital: Renal failure.
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