Prolix Mechanism of Action

Pharmacology: Pharmacodynamics: Tablet: The actions of prednisone as a strong anti-inflammatory agent account for its numerous beneficial effects in controlling manifestations of a wide range of clinical disorders.
Prednisone delivers broad and potent anti-inflammatory effects through multiple mechanisms.
Prednisone inhibits the production of inflammatory substances.
Prednisone has advantage over the other steroids because it exerts little effect on renal reabsorption while possessing very potent anti-inflammatory actions. It has very minimal salt-retaining properties.
Like other corticosteroids, prednisone is metabolized mainly in the liver but is also metabolized in other tissues. Prednisone is readily absorbed from the gastrointestinal tract following oral administration and is rapidly distributed to all body tissues.
In the liver, it is rapidly converted into a more active form, prednisolone, which has greater anti-inflammatory and less salt-retaining actions. Peak plasma concentration is obtained 1 to 2 hours after oral administration.
In the prednisolone form, it has a biological half-life of about 12-36 hours, so dosage may be adjusted to the functional pattern of circadian rhythm to decrease risk of adrenal insufficiency. Prednisone is extensively bound to plasma proteins. It is excreted in the urine as free and conjugated metabolites together with proportion of unchanged prednisolone. Small amounts of prednisolone are excreted in breast milk.
Pharmacodynamics: Suspension: Prednisone is a synthetic steroid which has advantage over the other steroids because it exerts little effect on renal reabsorption while possessing very potent anti-inflammatory effects. It has very minimal salt-retaining properties.
Prednisone is well-absorbed in the gastrointestinal tract following oral administration. In the liver, it is rapidly converted into a more active form, prednisolone, which has greater anti-inflammatory and less salt-retaining actions.
In the prednisolone form, it has a biological half-life of about 12-36 hours, so dosage may be adjusted to the functional pattern of circadian rhythm to decrease risk of adrenal insufficiency. Prednisone is used in a wide variety of clinical circumstances and disorders where its immunosuppressive properties may be beneficial.