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Click on icon to see table/diagram/imageIncidents of severe skin reactions, such as Stevens Johnson syndrome and Lyell's syndrome, with the use of acetylcysteine are very rare. In most cases at least one other drug was administered concomitantly, so the described mucocutaneous effects could be exacerbated. Immediate medical advice should be sought in case of onset of skin or mucosal changes and the use of acetylcysteine should be discontinued.
Various studies confirmed a decrease in platelet aggregation during administration of acetylcysteine. The clinical significance of this is unclear.
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