Platinox Special Precautions

Oxaliplatin should be administered under the supervision of a qualified physician experienced in the use of cancer chemotherapeutic agents. Appropriate management of therapy and complications is possible only when adequate diagnostic and treatment facilities are readily available.
The safety and effectiveness of the combination of oxaliplatin and 5-FU/LV in patients with renal impairment have not been evaluated. The combination of oxaliplatin and 5-FU/LV should be used with caution in patients with preexisting renal impairment since the primary route of platinum elimination is renal. Clearance of ultrafilterable platinum is decreased in patients with mild, moderate, and severe renal impairment. A pharmacodynamic relationship between platinum ultrafiltrate levels and clinical safety and effectiveness has not been established.
If nausea, vomiting, or loss of appetite occurs, ask your doctor or pharmacist for ways to lessen these effects. Also, other medicines may be given before and after therapy with oxaliplatin to help reduce these effects.
It is important to take each dose as scheduled. If you must miss a dose, contact your doctor who will establish a new dose schedule. Do not take 2 doses at once.
Oxaliplatin may cause drowsiness, dizziness, or vision changes. Do not drive, operate machinery, or do anything else that could be dangerous until you know how you react to oxaliplatin.
Do not reuse needles, syringes, or other materials. Dispose of properly after use. Ask your doctor, nurse, or pharmacist to explain local regulations for selecting an appropriate container and properly disposing of the container when full.
Oxaliplatin reduces the number of blood cells needed for clotting. To prevent bleeding, avoid situations in which bruising or injury may occur.
Oxaliplatin lowers your resistance to infection. To prevent infection, avoid contact with people who have colds or other infections. Do not touch your eyes or the inside of your nose unless you have thoroughly washed your hands first.
Check with your doctor before having vaccinations while you are using oxaliplatin.
Oxaliplatin may affect how your nerves feel and may cause sensitivity to cold temperatures. Avoid drinking cold drinks and using ice while receiving oxaliplatin. Cover exposed skin before exposing yourself to cold temperatures or cold objects.
Lab tests, including complete blood cell and hemoglobin counts, may be performed to monitor your progress. Be sure to keep all doctor and lab appointments.
If oxaliplatin contains particles or is discolored, or if the vial is cracked or damaged in any way, do not use it.
Use in Pregnancy & Lactation: Oxaliplatin has not been studied in pregnant women. However, studies in animals have shown that oxaliplatin causes miscarriages, decreased weight or death of the fetus, and problems with bone formation.
It is not known whether oxaliplatin passes into human breast milk. Oxaliplatin may cause serious side effects in the nursing infant, breast-feeding is not recommended while taking the medicine.