Sign Out
Therapy in Previously Treated Metastatic Cancer of the Colon or Rectum: Oxaliplatin dosage of 85 mg/m2 is administered by IV infusion on day 1 as part of a 2-day combination regimen that includes fluorouracil and leucovorin. The 2-day regimen may be repeated at intervals of 2 weeks.
Therapy in Previously Untreated and Previously Treated Patients with Advanced Colorectal Cancer: The recommended dose schedule given every two weeks is as follows:
Day 1: Oxaliplatin 85 mg/m2 IV infusion in 250-500 mL D5W and leucovorin 200 mg/m2 IV infusion in D5W both given over 120 minutes at the same time in separate bags using a Y-line, followed by 5-FU 400 mg/m2 IV bolus given over 2-4 minutes, followed by 5-FU 600 mg/m2 IV infusion in 500 mL D5W (recommended) as a 22-hour continuous infusion.
Day 2: Leucovorin 200 mg/m2 IV infusion over 120 minutes, followed by 5-FU 400 mg/m2 IV bolus given over 2-4 minutes, followed by 5-FU 600 mg/m2 IV infusion in 500 mL D5W (recommended) as a 22-hour continuous infusion.
Continue with Google