Oxalee Use In Pregnancy & Lactation

Use in Pregnancy: There are no adequate and well-controlled studies of oxaliplatin in pregnant women. However, based on direct interaction with DNA, oxaliplatin may cause fetal harm when administered to a pregnant woman. Reproductive toxicity studies in rats demonstrated adverse effects on fertility and embryo-fetal development at maternal doses that were below the recommended human dose. If this drug is used during pregnancy or if the patient becomes pregnant while taking this drug, the patient should be informed of the potential hazard to the fetus. Women of childbearing potential should be advised to avoid becoming pregnant and use effective contraception while receiving treatment and for 4 months after treatment with oxaliplatin.
Use in Lactation: It is not known whether oxaliplatin or its derivatives are excreted in human milk. Because many drugs are excreted in human milk and there is a potential for serious adverse reactions from oxaliplatin in breastfed infants, breastfeeding is contraindicated during oxaliplatin therapy.