Oxalee Dosage/Direction for Use

General Dosing Administration: Oxaliplatin lyophilized powder should be reconstituted and diluted prior to IV infusion.
Oxaliplatin is administered by intravenous infusion.
Dosage given should be adjusted according to tolerability.
If severe/life-threatening diarrhea, neurotoxicity or hematological toxicity occurs, a dose adjustment may be required.
Antiemetics (5-HT₃ blockers with or without dexamethasone) should be given during pre- and post-therapy with oxaliplatin since oxaliplatin is highly emetogenic.
Oxaliplatin should always be administered before fluoropyrimidines (i.e., 5-FU).
Oxaliplatin administration does not require prehydration.
Use only the recommended diluents in preparing the solution. (See Incompatibilities under Cautions for Usage).
General Dosing Instruction: Treatment of patients with advanced colorectal cancer: Oxaliplatin should be administered in combination with 5-fluorouracil/leucovorin every 2 weeks. For advanced disease, treatment is recommended until disease progression or unacceptable toxicity. For adjuvant use, treatment is recommended for a total of 6 months.
Day 1: Oxaliplatin 85 mg/m² (as IV infusion diluted in 250 to 500 mL of 5% Dextrose Solution) and leucovorin 200 mg/m² IV infusion in 5% Dextrose Solution both given over 120 minutes (2 hours) at the same time in different bags using a Y-line, followed by 5-FU 400 mg/m² by IV bolus given over 2 to 4 minutes, followed by 5-FU 600 mg/m² diluted in 500 mL 5% Dextrose Solution as a 22-hour continuous IV infusion.
Day 2: Leucovorin 200 mg/m² IV infusion over 120 minutes (2 hours), followed by 5-FU 400 mg/m² by IV bolus over 2 to 4 minutes, followed by 5-FU 600 mg/m² IV infusion in 500 mL 5% Dextrose Solution as a 22-hour continuous IV infusion. (See figure)

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Treatment may be repeated every 2 weeks.
For advanced or metastatic disease, treatment is recommended until disease progression or unacceptable toxicity.
Adjuvant treatment of patients with stage III (Duke's C) colon cancer who have undergone complete resection of primary tumor: Treatment is recommended for a total of 6 months (i.e., 12 cycles), given every 2 weeks, according to the dose schedule described previously for the treatment of patients with advanced colorectal cancer.
Or, as prescribed by a physician.
Dose Modification Recommendations: Oxaliplatin dosage adjustment is recommended according to the duration and severity of toxicities. Prior to subsequent therapy cycles, patients should be evaluated for clinical toxicities and recommended laboratory tests. Prolongation of infusion time for oxaliplatin from 2 to 6 hours may mitigate acute toxicities. The infusion times for 5-FU and leucovorin do not need to be changed. (See table.)

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Renal Impairment: In patients with normal renal function or mild to moderate renal impairment, the recommended oxaliplatin dose is 85 mg/m².
The initial recommended dose in patients with severe renal impairment should be reduced to 65 mg/ m².