Oncef Drug Interactions

Cautious treatment is required as renal insufficiency may be worsened with combination of similar compounds (other cephem antibiotics) and diuretics such as furosemide, etc.
Synergy between ceftriaxone and aminoglycosides has been demonstrated with many gram-negative bacilli under experimental conditions and it is of special importance in severe life-threatening infections due to micro-organisms such as Pseudomonas aeruginosa. Because of physical incompatibility the two drugs must administered separately at the recommended dosages. There is no evidence that ceftriaxone increases renal toxicity of aminoglycosides.
No effect similar to that of disulfiram has been demonstrated after ingestion of alcohol subsequent to the administration of ceftriaxone.
The elimination of ceftriaxone is not altered by probenecid.
Ceftriaxone does not contain an N-methylthiotetrazole moiety associated with possible ethanol intolerance and bleeding problems of certain other cephalosporins.
In vitro study antagonistic effects have been observed with the combination of chloramphenicol and ceftriaxone.