Oncef Caution For Usage

Reconstitution: Intramuscular injection: For I.M. injection, ceftriaxone 0.25 or 5.0 g is dissolved in 2 mL of 1% lidocaine. Therapy in general, administration of ceftriaxone 1 g in 3.5 mL of 1% lidocaine hydrochloride solution and injected well within the body of a relatively large muscle. It is recommended that not more than 1 g be injected at one site. I.M. injection without lidocaine solution is painful. The lidocaine solution never be administration intravenously.
Intravenous injection: For I.V injection, ceftriaxone 0.25 or 0.5 g is dissolved in 5 mL, and ceftriaxone 1 g in 10 mL sterile water for injections. The intravenous administration should be given over two to four minutes. In case of intravenous infusion, the infusion should last at least 30 minutes. For I.V. infusion, 2 g of ceftriaxone is dissolved in 40 mL of one of the following calcium-free infusion solutions sodium chloride 0.9%, sodium chloride 0.45% + dextrose 2.5%, dextrose 5%, dextrose 10%, dextran 6% in dextrose 5%, hydroxy ethyl starch 6-10% infusions or sterile water for injection. Ceftriaxone solution should not be mixed with or piggybacked into solutions containing other antimicrobial drug or into diluent solutions other than those listed previously, owing to possible incompatibility.
Reconstituted solutions retain their physical and chemical stability for six hours at room temperature or 24 hours at +25°C. As a general rule, however, the solution should be used immediately after preparation. They range in color from pale yellow to amber, depending on the concentration and the length of storage. This characteristic of the active ingredient is no significance for the efficacy or tolerance of the drug.