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Pregnancy: Ceftriaxone permeates placenta.
As safety in human pregnancy has not been established, it should not be administered to pregnant women or women bearing potential child unless therapeutic benefit is considered to exceed the possible risk.
Lactation: As the drug is excreted in the breastmilk at low concentration, caution is advised in nursing mothers.
Neonates and Prematures: Safety on neonates and prematures has not been established.
Studies have shown that ceftriaxone, like some other cephalosporins, can displace bilirubin from serum albumin. Special caution should be exercised on the development of bilirubin encephalopathy when considering it for hyperbilirubinemic neonates, especially prematures.
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