Numetrax Drug Interactions

Drug interactions: Cautious treatment is required as renal insufficiency may be worsened with combination of similar compounds (other cephalosporin antibiotics) and diuretics such as furosemide, etc.
Synergy between ceftriaxone and aminoglycosides has been demonstrated with many gram-negative bacilli under experimental conditions and it is of special importance in sever life-threatening infections due to microorganisms such as pseudomonas aeruginosa. Because of physical incompatibility the two drugs must be administered separately at the recommended dosages. There is no evidence that ceftriaxone increases renal toxicity of aminoglycosides.
No effect similar to that of disulfiram has been demonstrated after ingestion of alcohol subsequent to the administration of ceftriaxone.
The elimination of the drug is not altered by probenecid.
Ceftriaxone does not contain N-methylthiotetrazole moiety associated with possible ethanol intolerance and bleeding problems of certain other cephalosporins.
In an in-vitro study antagonistic effects have been observed with the combination of chloramphenicol and ceftriaxone.
Interference with laboratory test: Caution should be taken as urine glucose test using Benedict's reagent, Fehling's reagent, clinitest, except for test-tape reaction, may give false positive results.
Caution should be taken as direct Coombs-test may give false positive results.
Ceftriaxone, like other antibiotics, may result in false positive tests for galactosemia.