Mistol Special Precautions

Metronidazole has no direct effect on aerobic or facultative anaerobic bacteria.
Metronidazole should not be used for more than 10 days and no more than 2 or 3 times a year.
Alcohol consumption should be avoided during the therapy with metronidazole (disulfiram effect (see Interactions)).
There is a possibility of persisting gonococcal infection after elimination of trichomonal infection.
In dialysis patients metronidazole and its metabolites are eliminated in 8 hours after hemodialysis, hence metronidazole should be administered after hemodialysis.
Dose correction is not required in patients with renal insufficiency who undergo peritoneal dialysis.
In cases of ataxia, dizziness or confused mental state the therapy should be discontinued. Aggravation of neurological status should be considered in patients with severe, chronic or progressing diseases of the peripheral or central nervous system.
Patients with hematologic disorders in history or when administered high doses of the medicine and/or for a long duration of time are advised to undergo blood test especially for determination of the number of leukocytes.
Mistol should be administered with caution in patients with hepatic encephalopathy. Dose for patients with hepatic encephalopathy should be reduced to one third and can be administered once daily.
The continuation of the therapy in patients with leucopenia depends on severity the infectious disease.
When administered for a long period it is advised to monitor the patient for signs of adverse effects, such as, central or peripheral neuropathy (paresthesia, ataxia, dizziness, cramps).
Patients should be warned that metronidazole may darken urine (due to metronidazole active metabolite).
Administration of vaginal suppositories increases the chances of latex rupture when using condoms or diaphragms.
Effects On Ability to Drive and Use Machines: Patients should be warned about the potential for drowsiness, dizziness, confusion, hallucinations, convulsions or transient visual disorders, and advised not to drive or operate machinery if these symptoms occur.
Use in Children: The medicine is contraindicated for use in children.