Mistol Adverse Reactions

Gastro-intestinal system: Epigastric pain, nausea, vomiting, diarrhea; Inflammation of the mucous membrane of the mouth, glossitis with xerostomia, stomatitis, taste disturbances (metallic taste in the mouth), anorexia, coated tongue; Extremely rare - cases of pancreatitis, which are reversible.
Skin and subcutaneous tissue disorders: Hot flashes with hyperemia, itching, rash, which may be accompanied by fever; Urticaria, angioedema, rare - anaphylactic shock; Single cases of pustular eruptions and Erythema multiform.
Nervous system disorders: Peripheral sensory neuropathy; Headache, cramps, dizziness, ataxia, drowsiness; Very rare - encephalopathy (e.g. confused mental state, high body temperature, photosensitivity, torticollis, hallucinations, paralysis, vision impairment and movement disorder) and sub-acute cerebellar syndrome (e.g. ataxia, dysarthria, gait disorder, nystagmus, tremor), which may resolve on discontinuation of the drug; Aseptic meningitis.
Psychotic disorders: Psychotic disorders including confused mental state, hallucinations, depressed mood.
Eye disorders: Temporary vision impairment such as diplopia, myopia, blurred vision, impaired visual acuity, changes in color perception; Optic neuropathy/neuritis.
Blood disorders: In single cases - agranulocytosis, neutropenia, thrombocytopenia, pancytopenia and leucopenia.
Hepatobiliary disorders: In single cases - increase in liver enzyme levels (AST, ALT, alkaline phosphatase), cholangiolitic or mixed hepatitis and involvement of liver cells (hepatocytes), sometimes with jaundice; Reported cases of liver impairment, which required liver transplantation in patients undergoing treatment with metronidazole and other antibiotics.
Musculo-skeletal system and connective tissue disorders: Very rare - myodynia, arthrodynia.
Other side effects: High body temperature.
During the treatment urine may acquire red-brown color due to coloring agents as metronidazole metabolic products dissolve in water.