Mistol Mechanism of Action

Pharmacotherapeutic group: Gynecological anti infectives and antiseptics, imidazole derivatives. ATC code: G01AF01.
Pharmacology: Pharmacodynamics: Metronidazole belongs to nitro-5 imidazole and has a broad spectrum of action. Concentration limits that allow to differentiate susceptible (S) strains of moderate sensitivity and strains of moderate sensitivity - from resistant strains, are as follows: S <4 mg/L and R> 4 mg/L. Sensitive to the drug: Peptostreptococcus spp., Clostridium spp., Bacteroides spp., Fusobacterium spp., Porphyromonas, Bilophila, Helicobacter pylori, Prevotella spp., Veilonella. Metronidazole is holding back the development of the simplest - Trichomonas vaginalis, Giardia intestinalis (Lamblia intestinalis), Entamoeba histolytica. Steady sensitive to the drug: Bifidobacterium spp., Eubacterium spp. Insensitive microorganism strains: Propionibacterium, Actinomyces, Mobiluncus.
Pharmacokinetics: Following intravaginal administration systemic absorption is minimal. Plasma half-life is 8-10 hours. Plasma protein binding is small (less than 20%). There is rapid and considerable diffusion in the lungs, kidney, liver, bile, cerebro-spinal fluid, skin, saliva and vaginal secretions. It crosses the placental barrier and is excreted in breast milk. Metabolism is essentially hepatic: two non-conjugated oxidated active metabolites (5 to 30% activity) are formed. Excretion is chiefly urinary: 35 to 65% of the administered dose is excreted in urine in the form of metronidazole and its oxidated metabolites.