Lupinsulin 30:70 Special Precautions

Only a doctor can change an insulin dose or recommend to mix insulin preparations or to exchange one preparation for another.
Patient should inform a doctor if they develop any early manifestations of allergy to any insulin preparations, as well as other drugs, food, preservatives or dyes.
In patients who developed generalized reaction to insulin skin test should be conducted before the commencement of treatment with a new preparation.
During the insulin treatment glucose, HbA1 and fructosamine concentration in the blood serum and urine should be monitored.
Patients should learn how to check themselves their glucose concentration in urine and blood by using simple tests (e.g. Strip tests). In case it is not accurate they should promptly notify their doctor.
In different patients symptoms of a drop of glucose concentration in blood (hypoglycemia) may occur at different times with different strength. Patients then should learn how to recognize the characteristic for them hypoglycemic symptoms. If such symptoms occurs frequently, even with mild intensity, the patient should contact his/her doctor in order to change the insulin dose or diet.
Patients who change the animal insulin for human insulin may require a smaller dose of insulin (possibility of hypoglycemia). Some patients may not feel the early hypoglycemia symptoms after the human insulin administration as intensely as the animal insulin.
Also in patients with long lasting diabetes or diabetic neuropathy, or one who parallelly apply beta adrenolytical drugs and reached to balance their glucose level in blood, the early signs of hypoglycemia may also be weaker. Both hyperglycemia and hypoglycemia when not treated may lead to loss of consciousness, coma or death.
It is very important to keep to regular and diabetic meals.
The need of insulin lowers with a bigger physical effort; a more intensive exercise of the muscle insulin has been injected in intensive exercise of the muscle insulin has been injected in precipitates the hypoglycemia development (e.g. insulin injection in to a thigh before a run).
Patients who intend to change at least two time zones should consult a doctor to change the timing of insulin administration. During a flight insulin should be storage in hand-baggage not in the baggage hatch (insulin can get frozen).
The need for insulin may be altered by: high fever, severe infection (it may considerably increase the insulin need), emotional stress, sicknesses and disturbance of digestive tract with nausea, vomits, diarrhoea, low stomach discharge, absorption disturbances. Such conditions always require a consultation with a doctor. Glucose and if the results are correct, it is absolutely obligatory to consult a doctor. Recommended doses of insulin and regular meals should be observed.
Even medicine available over-the-counter (cold, fever, pain relief, appetite-reducing medicines) may alter the insulin need, therefore each time their application should be consulted with a doctor.
With kidneys failure the insulin elimination is reduced and its action time is longer.
Patients with diabetes due to pancreas sickness or diabetes that co-exist with Addison's sickness require very small doses of insulin.
In pituitary gland, suprarenal gland or thyroid gland disturbances the organism requirements of the insulin may alter.
Long-term insulin taking may generate an insulin resistance effect (see Adverse Reactions); in case insulin resistance effect occurs higher doses of insulin should be administered.
Effect on the ability of driving and operating machinery: The influence of the correct insulin dose administration on the ability of driving vehicle has not been examined. It may be handicapped by hyperglycemia that caused disturbances of the central nervous system with following symptoms: headaches, anxiety, double seeing, disorder of associations and distance evaluation. At the commencement of insulin treatment, change of insulin preparation, during stress or excessive physical effort-when considerable differences of glucose concentration in blood occur, disorder in ability of driving and operating machinery may happen. It is recommended to control the glucose concentration in blood during long journeys.