Lupinsulin 30:70 Mechanism of Action

Pharmacology: Pharmacokinetics: Absorption and Fate: Insulin has no hypoglycemic effect when administered by mouth since it is inactivated in the gastrointestinal tract.
It is fairly, rapidly absorbed from SC tissue following injection and although the t_½ in blood is very short (being only a matter of minutes), the duration of action of most preparations is considerably longer due to their formulation. The rate of absorption from different anatomical sites may be different and may also be increased by exercise. The absorption of insulin after IM administration is more rapid than that following SC administration. Human insulin may be absorbed slightly faster from SC tissue than porcine or bovine insulin.
Resistant to Insulin: The term insulin resistance has traditionally been used to describe a state which the diabetic patient exhibits considerably increased insulin requirements. It is now used in a much wider sense and in for instance, also applied to patients in whom a subnormal biological response to insulin can be demonstrated, although many of these patients do not apparently present difficulties in their clinical management.
Insulin is a hormone produced in the specialized pancreas cells. It participates in carbohydrates, fat and protein metabolism, causing among others, glucose lowering in blood serum. Insulin deficiency in organism causes diabetes. The injected insulin acts identically as the organism produced hormone.
The administered orally insulin is totally inactivated in the digestive tract and therefore the insulin preparations are administered in injections. Human insulin preparation Lupinsulin come in the following forms: Lupinsulin (plain clear solution), its therapeutic action starts within 30 minutes after administration and it reaches maximum effect 1-3 hours after the administration; the hypoglycemic effect of the preparations continues up to 8 hours and depends on the administered dose.
Milky white - Biphasic isophane suspension: mixture of Lupinsulin that therapeutic action starts within 30 minutes after administration, maximum effect between 2^nd and 8^th hour and the hypoglycemic effect continues up to 24 hours and depends on the administered dose.
In the healthy human about 5% of insulin is bound with blood proteins. Insulin was also detected in cerebrospinal fluid where its concentration constituted around 25% of total insulin concentration in the blood. Insulin is metabolized in liver and kidney. Some quantities of insulin are metabolized in muscle and fat tissue. Insulin is identically metabolized in healthy and diabetic humans. It is eliminated through kidneys. Minute quantities of insulin are eliminated with bile. The half-life of insulin is 4 minutes. Liver and kidneys sicknesses may delay insulin elimination. In elderly patients insulin elimination is slower and its hypoglycemic effect is prolonged.