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Renal failure and concurrent thiazide therapy predispose to hypersensitivity. Risk of precipitating acute gout during initial therapy is reduced by prophylactic doses of colchicine. Fluid intake should be sufficient to maintain urinary output not less than 2 L/day particularly when uricosurics are given concomitantly. Reduce dosage of allopurinol in renal failure. Liver and kidney function should be monitored and complete blood counts performed particularly during the 1st month of therapy.
Effects on the Ability to Drive or Operate Machinery: Impaired ability to operate motor vehicles or other dangerous machinery may occur.
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