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Allopurinol delays the metabolic breakdown of mercaptopurine and azathioprine; when these drugs are given concomitantly with allopurinol, ¼ of the usual dosage of mercaptopurine or azathioprines should be given. The t½ of anticoagulants, dicumarol, may be prolonged by allopurinol.
Coagulation time should be assessed if allopurinol is added to or removed from the patient's drug regimen.
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