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Linezolid should be used with caution in patients with renal impairment (creatinine clearance less than 30 mL/minute).
Although no dosage adjustment is required licensed product information states that the peak plasma concentrations of Linezolid's two major metabolites were about ten fold higher in such patients after several days of treatment. As about 30% of a dose is removed during 3 hours of hemodialysis it is recommended that Linezolid should be given after dialysis.
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