It is given by mouth in usual adult dose of 600 mg every 12 hours for 10 to 14 days treatment for up to 28 days may be necessary if there is vancomycin resistance. In uncomplicated skin and skin structure infections a dose of 400 mg by mouth every 12 hours for 10 to 14 days is usually sufficient. Children have more rapid clearance of Linezolid than adults.
Duration of treatment is the same as that for adults but with a basic regimen for those aged 7 days to 12 years of 10 mg/kg every 8 hours by mouth or intravenously neonates up to 7 days old should be given 10 mg/kg every 12 hours, although 8-hourly dosing may be considered if the clinical response is sub-optimal. For uncomplicated skin and skin structure oral doses every 12 hours are sufficient in those aged 5 to 11 years. Or as prescribed by the physician.
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