Levox Dosage/Direction for Use

Tablet: Adult Dose: Orally, 250 to 500 mg once daily.
Administer the dose at least two hours before or two hours after antacids containing magnesium, or aluminum; after sucralfate or metal cations such as iron, and multivitamin preparations with zinc. Concomitant administration with these drugs may significantly decrease Levofloxacin absorption.
Vial: Levofloxacin solution should only be administered by intravenous infusion. It is not for intramuscular, intrathecal, intraperitoneal, or subcutaneous administration.
Caution: Rapid or bolus intravenous infusion must be avoided.
Usual dose: 500 mg administered by slow infusion over 60 minutes every 24 hours or 750 mg administered by slow infusion over 90 minutes every 24 hours.
It is usually possible to switch from initial intravenous treatment to the oral route after a few days, depending on patient's condition.
As with antibiotic therapy in general, administration of Levofloxacin solution for infusion should be continued for a minimum of 48 to 72 hours after the patient has become afebrile or evidence of bacterial eradication has been obtained.
750 mg Infusion: Patients receiving oral or intravenous (IV) levofloxacin should be well hydrated to prevent formation of highly concentrated urine. Crystalluria and cylinduria have been reported with quinolones.
Levofloxacin should be given or taken at the same time each day.
Levofloxacin solution for infusion should only be administered by IV infusion. It is NOT for intramuscular, intrathecal, intraperitoneal, or subcutaneous administration.
Caution: Rapid or bolus IV infusion must be avoided because it may result to hypotension.
Usual Recommended Dose: 750 mg administered by slow IV infusion over 90 minutes once every 24 hours. The dose and duration of treatment are based on the type and severity of infection being treated (see Dosing Table).
As with other parenteral antibiotic therapy in general, administration of levofloxacin solution for infusion should be continued for a minimum of 48 to 72 hours after the patient has become afebrile or evidence of bacterial eradication has been obtained. It is usually possible to switch from initial IV treatment to the oral route after a few days, depending on the patient's condition and the physician's discretion.
Levofloxacin IV Dosing in Adult Patients with Normal Renal Function (creatinine clearance ≥ 50 mL/min): See Tables 3 and 4.

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When only the serum creatinine value is available, the following formula may be used to estimate creatinine clearance. The serum creatinine should represent a steady state of renal function: See Equation.

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Levofloxacin Oral or IV Dosing in Children: See Table 5.

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Or, as prescribed by a physician.