Levexime Special Precautions

Special care is indicated in patients who have experienced an allergic reaction to penicillins or other beta-lactams.
Safety in pregnancy and lactation has not been established.
Cefuroxime does not interfere in enzyme-based tests for glucosuria. Slight interference with copper reduction methods (Benedict's, Fehling's, Clinitest) may be observed. However, this should not lead to false-positive results. Cefuroxime may cause false-negative reactions in the ferricyanide test. Some cephalosporins can cause a falsely high reading in the alkaline picrate assay for creatinine, although the degree of elevation is unlikely to be of clinical importance. It is possible that cefuroxime may also interfere with this determination.
Prolonged use may result in the overgrowth of non-susceptible organisms. Patients developing frequent loose stools should be carefully monitored for the possible development of an antibiotic colitis.
Concomitant use of cefuroxime and furosemide should be avoided when possible. If they are used together renal function should be monitored closely as furosemide may enhance the nephrotoxic potential of the cephalosporins.
The combined use of cephalosporins and aminoglycosides seems to increase the risk of nephrotoxicity and should be undertaken with caution and with close monitoring of renal function. Cefuroxime must not be administered simultaneously with other medicines.