Levexime Side Effects

Effects reported include rashes, thrombophlebitis after intravenous injection, gastrointestinal disturbance and Candida intertrigo. The principal changes in haematological parameters seen in some patients have been of unexplained decreased haemoglobin concentration and of eosinophilia. Patients developing eosinophilia should have renal function closely monitored since hypersensitivity with acute renal failure has previously been documented. Patients developing decreased haemoglobin concentration should have bone marrow response monitored. Leukopenia and neutropenia have also been noted.
A positive Coombs' test has been found in patients treated with cefuroxime, this phenomenon can interfere with the cross-matching of blood. There are sometimes rises in serum liver enzymes or serum bilirubin particularly in patients with pre-existing liver disease. There may also be some variation in the results of biochemical tests of renal function but these do not appear to be of clinical importance.
As a precaution, renal function should be monitored if this is already impaired. Hypersensitivity reactions including skin rashes (maculopapular and urticarial), drug fever and anaphylaxis have been reported.
Transient pain may be experienced at the site of intramuscular injection. This is more likely to occur with higher doses. However, it is unlikely to be a cause for discontinuation of treatment.