Kinetica Overdosage

Overdose and treatment: The largest accidental overdose reported in premarketing clinical trials was 435 mg ingested over for a seven-day period (62.1 mg/day). The following symptoms were observed in patients who had accidental ropinirole overdose of more than 24 mg/day: orofacial dyskinesia, intermittent nausea, agitation, increased dyskinesia, grogginess, sedation, orthostatic hypotension, chest pain, confusion, vomiting, visual hallucinations, hyperhidrosis, claustrophobia, chorea, palpitations, asthenia, and nightmares. Additional overdose symptoms include increased coughing, fatigue, syncope, and vasovagal syncope.
The symptoms of ropinirole overdose are related to its dopaminergic activity. Symptoms of overdose may be managed by appropriate treatment with dopamine antagonists, such as neuroleptics or metoclopramide. However, the efficacy of these drugs in reversing the effects of overdose has not been assessed. General supportive measures should be provided to the patient, and vital signs should be maintained, if necessary. Cardiovascular monitoring is also recommended.