Kinetica Adverse Reactions

The most common adverse events associated with ropinirole include nausea, dizziness (including vertigo), somnolence, sudden onset of sleep, headache, hallucinations, peripheral edema, vomiting, abdominal pain or discomfort, syncope, fatigue, viral infection, and dyskinesia.
Infections and infestations: Abscess, bacterial infection, bronchitis, candidiasis, fungal infection, herpes simplex, infections, nasopharyngitis, periodontitis, poliomyelitis, sepsis, upper respiratory tract infection, urinary tract infection.
Neoplasms benign, malignant and unspecified (including cysts and polyps): Adenocarcinoma, basal cell carcinoma, benign brain neoplasm, bladder carcinoma, brain neoplasm, breast fibroadenosis, carcinoma, dermoid cyst, esophageal carcinoma, lipoma, malignant female breast neoplasm, fungal dermatitis, malignant endometrial neoplasm, malignant larynx neoplasm, malignant lymphoma, malignant neoplasm, malignant skin neoplasm, neoplasm, prostate adenocarcinoma, rectal carcinoma, uterine neoplasm.
Blood and lymphatic system disorders: Anemia, eosinophilia, granulocytopenia, hypochromic anemia, leukocytosis, leukopenia, lymphadenopathy, lymphopenia, lymphedema, lymphocytosis, polycythemia, thrombocytopenia, vitamin B12 deficiency anemia.
Immune system disorders: Angioedema, hypersensitivity.
Endocrine disorders: Goiter, hypothyroidism, syndrome of inappropriate antidiuretic hormone secretion, hyperthyroidism.
Metabolism and nutrition disorders: Acidosis, aggravated diabetes mellitus, anorexia, dehydration, diabetes mellitus, electrolyte imbalance, enzyme abnormality, fluid overload, generalized edema, gout, hypercholesterolemia, hyperglycemia, hyperkalemia, hyperphosphatemia, hyperuricemia, hypochloremia, hypoglycemia, hypokalemia, hyponatremia, increased appetite, lactose intolerance, obesity, thirst, weight loss.
Psychiatric disorders: Abnormal dreams, agitation, aggravated depression, aggression, anxiety, apathy, binge eating, compulsive shopping, confusion, delirium, delusion, depersonalization, depression, disturbance in attention, dopamine dysregulation syndrome, drowsiness, emotional lability, euphoria, gambling disorder, hypersexuality, illusion, impulse control disorder, insomnia, manic reaction, major depression, neurosis, nightmare, paranoia, personality disorder, psychosis, psychotic disorder, sleep disorder, somnambulism, suicide attempt, thinking abnormal.
Nervous system disorders: Abnormal coordination, abnormal gait, aggravated Parkinson's disease, amnesia, aphasia, ataxia, blepharospasm, carpal tunnel syndrome, cerebral atrophy, choreoathetosis, coma, convulsions, dementia, dysphonia, dystonia, extrapyramidal disorder, generalized tonic-clonic seizure, hemiparesis, hemiplegia, hydrocephalus, hypoesthesia, hyperesthesia, hyperkinesia, hyperreflexia, hypertonia, hypokinesia, hypotonia, involuntary muscle contractions, migraine, mental status change, neuroma, nervousness, neuralgia, nerve root lesion, neuropathy, paresis, paresthesia, peripheral neuropathy, paralysis, ptosis, sensory disturbance, speech disorder, stupor, tremor, vocal cord paralysis.
Eye disorders: Accommodation disorder, abnormal lacrimation, blepharitis, blindness, cataract, conjunctivitis, diplopia, eye disorder, eye pain, hemianopia, glaucoma, keratitis, macular degeneration, periorbital edema, photophobia, retinal disorder, scotoma, transient blindness, visual impairment, xerophthalmia.
Ear and labyrinth disorders: Deafness, ear disorder, ear pain, hyperacusis, hypoacusis, otitis media, tinnitus, vestibular disorder.
Cardiac disorders: Aggravated angina pectoris, angina pectoris, arrhythmia, atrial fibrillation, atrioventricular block, bradycardia, bundle branch block, cardiac arrest, cardiac failure, cardiac valve disease, cardiomegaly, chest pain (precordial, substernal), extrasystoles, heart disorder, mitral valve incompetence, myocardial infarction, palpitations, supraventricular extrasystoles, supraventricular tachycardia, tachycardia, ventricular tachycardia.
Vascular disorders: Aggravated hypertension, aneurysm, angiopathy, arteritis, atherosclerosis, cerebrovascular disorder, cyanosis, deep vein thrombosis, flushing, gangrene, hematoma, hemorrhoids, hypertension, hypotension, ischemic necrosis, orthostatic hypotension, pallor, peripheral embolism, peripheral ischemia, phlebitis, superficial phlebitis, systolic hypertension, systolic orthostatic hypotension, thrombophlebitis, thrombosis, varicose vein, vein disorder.
Respiratory, thoracic, and mediastinal disorders: Asthma, bronchitis, cough, dyspnea, epistaxis, hypoxia, increased sputum, influenza, interstitial pulmonary disease, laryngitis, nasal congestion, parosmia, pharyngitis, pleural effusion, pleurisy, pneumonia, pulmonary edema, pulmonary embolism, respiratory disorder, respiratory failure, rhinitis, sinusitis, yawning.
Gastrointestinal disorders: Abdominal distension, aggravated tooth caries, altered saliva, constipation, colitis, diarrhea, diverticulitis, dry mouth, duodenal ulcer, duodenal ulcer hemorrhage, duodenitis, dysgeusia, dyspepsia, dysphagia, esophageal stricture, esophageal ulcer, esophagitis, fecal incontinence, flatulence, gastric ulcer, gastritis, gastroenteritis, gastroesophageal reflux disorder, gastrointestinal disorder, gastrointestinal hemorrhage, gingival bleeding, gingivitis, glossitis, halitosis, hematemesis, hemorrhagic gastritis, hiccup, increased salivation, melena, mouth ulceration, pancreatitis, peptic ulcer, rectal disorder, rectal hemorrhage, salivary duct obstruction, salivary hypersecretion, stomatitis, tenesmus, tongue disorder, tongue edema, toothache, tooth caries, tooth disorder, xerostomia.
Hepatic and hepatobiliary disorders: Abnormal hepatic function, aggravated bilirubinemia, ascites, biliary colic, bilirubinemia, cholecystitis, cholelithiasis, gall bladder disorder, hepatic reactions, hepatocellular damage.
Skin and subcutaneous tissue disorders: Aggravated psoriasis, alopecia, bullous eruption, cellulitis, dermatitis, dry skin, eczema, furuncle, herpes zoster, hyperkeratosis, nail disorder, nevus, photosensitivity allergic reaction, photosensitivity reaction, pruritus, psoriasis, purpura, rash, rash erythematous, rash maculopapular, rash psoriaform, seborrhea, skin discoloration, skin disorder, skin exfoliation, skin hypertrophy, skin ulcer, urticaria.
Musculoskeletal and connective tissue disorders: Aggravated arthritis, arthralgia, arthritis, arthropathy, back pain, bone disorder, bursitis, Dupuytren's contracture, leg cramps, limb pain, muscle atrophy, muscle cramps, muscle spasms, muscular weakness, myalgia, myositis, osteoporosis, polymyalgia rheumatica, rheumatoid arthritis, rigors, skeletal pain, spine malformation, tendonitis, torticollis.
Renal and urinary disorders: Abnormal urine, acute renal failure, albuminuria, bladder calculus, cystitis, dysuria, glycosuria, hematuria, micturition disorder, micturition frequency, nephritis, nocturia, oliguria, polyuria, pyelonephritis, pyuria, renal calculus, renal cyst, renal pain, uremia, urethral disorder, urinary incontinence, urinary retention.
Reproductive system and breast disorders: Amenorrhea, balanoposthitis, decreased libido, dysmenorrhea, epididymitis, ejaculation disorder, ejaculation failure, female breast enlargement, genital candidiasis, gynecomastia, impotence, increased libido, metrorrhagia, mastitis, menstrual disorder, penis disorder, perineal pain, Peyronie's disease, prostatic disorder, testicular disorder, uterine disorders, uterine hemorrhage, vaginal hemorrhage.
General disorders and administration site conditions: Asthenia, cold sweat, decreased therapeutic response, dopamine agonist withdrawal syndrome, face edema, fever, gravitational edema, hyperhidrosis, increased therapeutic response, influenza-like illness, malaise, pain.
Investigations: Abnormal electrocardiogram, decreased blood pressure, decreased diastolic blood pressure, decreased heart rate, decreased serum iron, decreased systolic blood pressure, decreased weight, increased alanine aminotransferase, increased alkaline phosphatase, increased amylase, increased aspartate aminotransferase, increased blood urea nitrogen, increased creatine phosphokinase, increased drug level, increased gamma-glutamyltranspeptidase levels, increased heart rate, increased hepatic enzymes, increased lactate dehydrogenase, increased phosphokinase, increased thyroxine, increased weight, urinary casts.
Injury, poisoning and procedural complications: Fall, injury, subarachnoid hemorrhage, vitreous detachment.