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Nitrates may cause hypotension as a result of peripheral vasodilation. Alcohol may enhance this effect. Patients who are prescribed isosorbide dinitrate should be cautioned accordingly.
Patients receiving antihypertensive drugs, beta adrenergic blockers, or phenothiazines with nitrates should be observed for possible additive hypotensive effects.
Sildenafil: See Precautions.
Riociguat: See Contraindications.
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