Isordil Adverse Reactions

Cutaneous vasodilation with flushing may occur.
Vascular headache is common and may be severe and persistent. Headache is usually relieved by the use of suitable analgesics, or by a temporary reduction in dosage, and tends to disappear after the first week or two of use.
Transient episodes of dizziness and weakness, as well as other signs of cerebral ischemia associated with postural hypotension, may occasionally develop. Occasional individuals may exhibit marked sensitivity to the hypotensive effects of nitrates, even with the usual therapeutic dosage. Severe responses such as nausea, vomiting, weakness, restlessness, pallor, perspiration, and collapse can be manifested. Alcohol may intensify this effect. Measures which facilitate venous return (e.g. head-low or Trendelenburg position, deep breathing movement of extremities) will usually reverse the syndrome.
Drug rash and/or exfoliative dermatitis may occasionally occur.
Nausea and vomiting appear to be uncommon.