The amount of nutrients in this medicine is relatively nontoxic and is usually well tolerated. However, undesirable effects may occur, particularly when the nutrients are used at high doses.
Ascorbic acid (Vitamin C): Blood and lymphatic system disorders: Hemolysis [after large oral doses of ascorbic acid in patients with glucose-6-phosphate dehydrogenase (G6PD) deficiency].
Immune system disorders: Delayed-type allergic response.
Psychiatric disorders: Insomnia, sleepiness.
Nervous system disorders: Headache.
Vascular disorders: Flushing.
Gastrointestinal disorders: Abdominal cramps, diarrhea (at a dose of 1 g or more daily), esophagitis (rare), flatulent distention, gastric discomfort, heartburn, intestinal obstruction (rare), nausea, transient colic, vomiting.
Renal and urinary disorders: Increased urination (mild), kidney stone formation (associated with large dosages of ascorbic acid reportedly have been limited to individuals with preexisting renal disease).
Zinc: Blood and lymphatic system disorders: Anemia (abnormally low red blood cell count), blood cell microcytosis (condition where red blood cells are smaller than normal), neutropenia (abnormally low neutrophil count).
Metabolism and nutrition disorders: Disturbance of copper metabolism, loss of appetite, reduced iron function.
Psychiatric disorders: Drowsiness.
Nervous system disorders: Headache, metallic taste.
Gastrointestinal disorders: Abdominal pain/cramps, diarrhea, dyspepsia, gastritis (inflammation of the stomach), gastrointestinal discomfort/irritation, nausea, vomiting.
Colecalciferol (Vitamin D3): Metabolism and nutrition disorders: Hypercalcemia (high blood calcium levels).
Cardiac disorders: Cardiac arrhythmia (irregular heartbeat).
Gastrointestinal disorders: Constipation, nausea, vomiting.
Renal and urinary disorders: Hypercalciuria (high calcium levels in the urine), nephrolithiasis (kidney stones), nocturia (need to pass urine at night), polyuria (excessive urination).
General disorders and administration site conditions: Polydipsia (excessive thirst).