Ascorbic acid (Vitamin C): Blood and lymphatic system disorders: Hemolysis [after large oral doses of ascorbic acid in patients with glucose-6-phosphate dehydrogenase (G6PD) deficiency].
Immune system disorders: Delayed-type allergic response.
Psychiatric disorders: Insomnia, sleepiness.
Nervous system disorders: Headache.
Vascular disorders: Flushing.
Gastrointestinal disorders: Abdominal cramps, diarrhea (at a dose of 1 g or more daily), esophagitis (rare), flatulent distention, gastric discomfort, heartburn, intestinal obstruction (rare), nausea, transient colic, vomiting.
Renal and urinary disorders: Increased urination (mild), kidney stone formation (associated with large dosages of ascorbic acid reportedly have been limited to individuals with preexisting renal disease).
Zinc: Blood and lymphatic system disorders: Anemia (abnormally low red blood cell count), blood cell microcytosis (condition where red blood cells are smaller than normal), neutropenia (abnormally low neutrophil count).
Metabolism and nutrition disorders: Disturbance of copper metabolism, loss of appetite, reduced iron function.
Psychiatric disorders: Drowsiness.
Nervous system disorders: Headache, metallic taste.
Gastrointestinal disorders: Abdominal pain/cramps, diarrhea, dyspepsia, gastritis (inflammation of the stomach), gastrointestinal discomfort/irritation, nausea, vomiting.
Colecalciferol (Vitamin D3): Metabolism and nutrition disorders: Hypercalcemia (high blood calcium levels).
Cardiac disorders: Cardiac arrhythmia (irregular heartbeat).
Gastrointestinal disorders: Constipation, nausea, vomiting.
Renal and urinary disorders: Hypercalciuria (high calcium levels in the urine), nephrolithiasis (kidney stones), nocturia (need to pass urine at night), polyuria (excessive urination).
General disorders and administration site conditions: Polydipsia (excessive thirst).
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