Hypace Dosage/Direction for Use

Hypertension: Initial Dose: 5 mg daily. Usual dosage range: 10 to 40 mg per day as a single dose or two divided doses. In some patients treated once daily, the antihypertensive effect may diminish toward the end of the dosing interval. In such patients, consider increasing dose or administering twice daily.
Dosage Adjustment in Hypertensive Patients with Renal Impairment: The usual dose of enalapril maleate (Hypace) is recommended for patients with a creatinine clearance >30 mL/min (serum creatinine of up to approximately 3 mg/dL). For patients with creatinine clearance ≤30mL/min (serum creatinine ≥3 mg/dL), the first dose is 2.5 mg once daily. The dosage may be titrated upward until blood pressure is controlled or to a maximum of 40 mg daily.
Heart Failure: Initial Dose: 2.5 mg daily. Maintenance Dose: 20 mg daily as a single dose or in 2 divided doses. Recommended dosing range: 2.5 to 20 mg given twice a day. Maximum daily dose: 40 mg in divided doses.
Asymptomatic Left Ventricular Dysfunction: Initially, 2.5 mg twice daily. Titrate as tolerated to the targeted daily dose of 20 mg (in divided doses).
Dosage Adjustment in Patients with Heart Failure and Renal Impairment or Hyponatremia: In patients with heart failure who have hyponatremia (serum sodium less than 130 mEq/L) or with serum creatinine greater than 1.6 mg/dL, therapy should be initiated at 2.5 mg daily under close medical supervision. The dose may be increased to 2.5 twice a day, then 5 mg twice a day and higher as needed, usually at intervals of four days or more if at time of dosage adjustment there is not excessive hypotension or significant deterioration of renal function. Maximum daily dose: 40 mg.
Pediatric Hypertensive Patients: Antihypertensive effects of enalapril maleate (Hypace) have been established in hypertensive pediatric patient’s age 1 month to 16 years. Recommended starting dose: 0.08 mg/kg (up to 5 mg) once daily. Doses above 0.58 mg/kg (or in excess of 40 mg) have not been studied in pediatric patients.
Administration: It should be taken with food or immediately after meals.