Gracefix Special Precautions

Care is also necessary in patients with history of allergy.
Cefixime should be given with caution to patients with renal impairment, dosage reduction may be necessary. Cefixime may interfere with the Jaffe's method of measuring creatinine concentrations and may produce falsely high values; this should be borne in mind when measuring renal functions. Positive results to the direct Coombs' test have been found during treatment with cefixime and these can be interfering with blood cross matching. The urine of patients being treated with cefixime may give false reaction for glucose using copper reduction reactions.
Use in pregnancy: The safety of cefixime in the treatment of infection in pregnant women has not been established. Reproduction studies have been performed in mice and rats at doses up to 400 times the human dose and have revealed no evidence of impaired fertility or harm to the fetus due to cefixime. Because animal reproduction studies are not always predictive of human response, this drug should be used during pregnancy only if the likely benefits of using cefixime outweighs the potential risk to the fetus and/or the mother.